Peptide Research Index
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
Also: MT-II, MT-2
Melanocortin AgonistLast Updated: April 1, 2026
Melanotan II (also known as MT-II, MT-2) is a prominently researched experimental compound classified strictly within the Melanocortin Agonist framework. Operating primarily through advanced pharmacological pathways, it functions by mC4R activation. Non-selectively activates melanocortin receptors to stimulate melanin production, suppress appetite, and increase sexual arousal. with a documented biological half-life of roughly 1 hours, in preclinical investigative trials and independent academic studies, researchers utilizing Melanotan II have documented significant, quantifiable biological outcomes, primarily focusing on tanning, libido enhancement. Typical research protocols investigate administering 250 to 250mcg via subq pathways 7x/wk. However, it is critically important to understand that while Melanotan II demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.
MC4R activation. Non-selectively activates melanocortin receptors to stimulate melanin production, suppress appetite, and increase sexual arousal.
Dorr et al. (J. Investigative Dermatol.): Phase I trial in normal male volunteers confirming tanning activity and spontaneous penile erections. Side effects: nausea, somnolence.
moderateWessells et al. (J. Urology): Double-blind study showing MT-II initiates erection in men with erectile dysfunction even without sexual stimulation.
moderateHadley & Dorr (Peptides): Review of MT-II as potential chemopreventive agent for UV-induced skin cancer through enhanced eumelanin synthesis.
preclinicalHruby et al. describe development of functionally selective melanocortin receptor agonists derived from MT-II to separate desired from unwanted pharmacological effects.
preclinicalNausea common; research-only. SIGNIFICANT SAFETY CONCERNS: changes to moles, elevated BP. Actively warned against by FDA/TGA.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Loading: 250mcg/day for 7-10 days. Maintenance: as needed for UV exposure. START LOW.
Last updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
Week 1
Nausea common during initial dose; spontaneous erections in men; early tanning begins
Weeks 2-4
Significant skin pigmentation; libido effects
Long-term
Persistent tan maintained with UV exposure; long-term safety concerns with mole changes
| Side Effect | Incidence | Severity |
|---|---|---|
Nausea Most common side effect; dose-dependent | ~45% of users | moderate |
Facial flushing | ~30% of users | mild |
Fatigue | ~15% of users | mild |
Spontaneous erections (men) | ~20% of men | mild |
Mole changes (darkening) Monitor moles carefully; can mask melanoma | Variable | uncommon |
Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.
Finding verified, high-purity Melanotan II requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
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PeptiDex. (2026). Melanotan II. PeptiDex Research Platform. https://peptidex.app/library/melanotan-ii
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