Peptide Research Index
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
Also: NN9838, AM833
MetabolicLast Updated: April 1, 2026
Cagrilintide (also known as NN9838, AM833) is a prominently researched experimental compound classified strictly within the Metabolic framework. Operating primarily through advanced pharmacological pathways, it functions by long-acting amylin analog that activates amylin receptors in the area postrema and hypothalamus to reduce appetite, slow gastric emptying, and suppress post-meal glucagon secretion. Works on a distinct pathway from GLP-1 agonists, making it ideal for combination therapy. with a documented biological half-life of roughly 168 hours, in preclinical investigative trials and independent academic studies, researchers utilizing Cagrilintide have documented significant, quantifiable biological outcomes, primarily focusing on weight loss, appetite reduction, glycemic control. Typical research protocols investigate administering 500 to 4500mcg via subq pathways weekly. However, it is critically important to understand that while Cagrilintide demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.
Long-acting amylin analog that activates amylin receptors in the area postrema and hypothalamus to reduce appetite, slow gastric emptying, and suppress post-meal glucagon secretion. Works on a distinct pathway from GLP-1 agonists, making it ideal for combination therapy.
Lau et al. (Lancet): Phase 2 RCT showing cagrilintide 4.5mg weekly achieved 10.8% weight loss vs 3.0% placebo at 26 weeks, with acceptable safety profile.
strongFrias et al. (Lancet): CagriSema combination achieved 15.6% weight loss at 32 weeks in type 2 diabetes patients — superior to either agent alone.
strongReview of amylin's role in energy homeostasis and why dual amylin-calcitonin receptor agonists like cagrilintide represent a new weight loss mechanism distinct from GLP-1.
moderateGenerally well-tolerated in Phase 2 trials. Main side effects are GI-related (nausea, vomiting). Novo Nordisk is developing CagriSema (cagrilintide + semaglutide) as next-gen obesity treatment. Research-only peptide.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Clinical trial doses: 0.3-4.5mg weekly with dose escalation over 4-8 weeks. Start low (0.3-0.6mg) and increase every 4 weeks to minimize GI side effects.
Week 1
Appetite suppression begins; reduced food cravings
Weeks 2-4
Measurable weight loss (1-2 lbs/week); improved meal portion control
Month 2-3
10-11% body weight loss at clinical doses; improved glycemic markers
Long-term
Clinical trials show sustained weight loss through 26+ weeks; CagriSema in Phase 3 trials
| Side Effect | Incidence | Severity |
|---|---|---|
Nausea Most common during dose escalation; typically resolves in 2-4 weeks | ~25% of users | moderate |
Diarrhea | ~10% of users | mild |
Vomiting | ~8% of users | moderate |
Injection site reaction | ~5% of users | mild |
Constipation | ~8% of users | mild |
Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.
Finding verified, high-purity Cagrilintide requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
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PeptiDex. (2026). Cagrilintide. PeptiDex Research Platform. https://peptidex.app/library/cagrilintide
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