COMPOUND5-Amino-1MQ
ALIAS5-Amino-1-Methylquinolinium
CLASSNNMT Inhibitor
HALF-LIFENot fully characterized
MW159.2 Da
FDA STATUSNot approved
BEST PRICE$7.50/mg (Bio Longevity Labs + PEPTIDEX)
LAST VERIFIEDMay 2026
5-Amino-1MQ
Last reviewed May 15, 2026
Also known as: 5-amino-1-methylquinolinium, 5A1MQ
Quick Answer
5-Amino-1MQ is an NNMT inhibitor with emerging research on adipose tissue metabolism and energy expenditure — the Neelakantan et al. 2022 study showed significant fat mass reduction in diet-induced obese mice without affecting lean mass. I've been tracking the metabolic data on this compound closely. For sourcing, Bio Longevity Labs carries 10mg vials at $74.97. Use code PEPTIDEX for 15% off (stacks with sales).
Where to Source
Ranked by $/mg1Bio Longevity Labs Best $/mg
$63.72
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10mg vial
$7.50/mg
99%+ purityTested May 2026
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Rankings independent · Research use only
Selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM and depletes NAD+ pools while promoting fat storage. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ l
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
Where to Buy 5-Amino-1MQ
COA-verified vendors · Use code PEPTIDEX for up to 20% off
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Bio Longevity LabsTriple-Tested | 99%+ | $74.97/10mg | $63.72Save 15% | PEPTIDEX | Shop |
Bio Longevity LabsTriple-Tested
$74.97/10mg$63.72−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
Shop at Bio Longevity LabsAffiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links. This does not affect our editorial ranking. See our methodology. Prices shown are list prices at time of last update — verify on vendor site.
§ Mechanism of Action
Selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM and depletes NAD+ pools while promoting fat storage. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ levels, activates SIRT1, and shifts adipocytes toward lipolysis. Shown in rodent models to reduce fat mass without caloric restriction.
§ Primary Benefits
- 1Fat loss
- 2NAD+ preservation
- 3metabolic optimization
- 4muscle protection
§ Clinical Evidence
NNMT inhibition induces browning of white adipose tissue and reduces fat mass
Neelakantan et al. demonstrate that selective NNMT inhibitor treatment in obese mice significantly reduces fat mass, increases energy expenditure, and upregulates brown adipose tissue markers without affecting food intake.
PreclinicalNNMT inhibition protects against diet-induced obesity
Kraus et al. (Nature Communications): NNMT inhibition in mice prevents diet-induced obesity and improves insulin sensitivity by increasing NAD+ and methylation capacity in adipose tissue.
Preclinical§ Safety Profile
⚠ PRECLINICAL RESEARCH ONLY. No completed human clinical trials. All efficacy and safety data derived from rodent models. Do not extrapolate to human dosing. Oral bioavailability and pharmacokinetics in humans are not established.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
RouteOral
Dose Range50000–100000 mcg
FrequencyDaily
Rodent study doses extrapolated to ~50-100mg human equivalent. No validated human protocol exists. Research use only.
§ Pharmacokinetics
⏱️ Half-Life: 2h
Plasma concentration over time§ Expected Outcomes
Weeks 2–4
Rodent models show measurable fat mass reduction and NAD+ elevation at 4 weeks
Month 2–3
Sustained fat mass reduction observed in diet-induced obesity models
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Unknown in humans No human safety data available | Not established | rare |
Where to Source 5-Amino-1MQ for Research
Finding verified, high-purity 5-Amino-1MQ requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified 5-Amino-1MQ✓ Third-party tested·✓ US shipping·✓ COA on every batch
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5-Amino-1MQ is the NNMT inhibitor I've been tracking for its novel mechanism — it doesn't work through traditional appetite suppression or GLP-1 pathways. Instead, it targets nicotinamide N-methyltransferase, an enzyme that when inhibited, shifts cellular metabolism toward higher energy expenditure.
The Neelakantan et al. 2022 study in Biochemical Pharmacology demonstrated significant fat mass reduction in diet-induced obese mice without affecting lean mass or food intake. That selectivity — fat loss without appetite suppression — is what makes the NNMT pathway interesting as a research target.
Amino Club batch AMQ0001 verified at 99.710% purity via Biogenica Labs. Some vendors sell 5-Amino-1MQ as an oral capsule rather than injectable, which changes the bioavailability calculations. COA PDF for batch AMQ0001 linked below.
📄 View COA: AMQ0001 (99.71% HPLC, 172.2 Da)Full disclosure — PEPTIDEX is my affiliate code. Amino Club and Bio Longevity Labs both carry 5-Amino-1MQ.
Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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⚠ Educational only · Not medical advice · Most peptides are research-only / not FDA-approved