Fat loss.
The peptide landscape for fat loss has exploded since GLP-1 agonists went mainstream. From FDA-approved options like Semaglutide and Tirzepatide to research compounds like Retatrutide and AOD-9604, there are now multiple evidence-backed pathways to accelerate fat loss.
Looking for Semaglutide or Tirzepatide?
This page focuses on synergistic peptide stacks. If you are researching standalone GLP-1 agonists and their non-incretin alternatives (like Tesofensine or AOD-9604), view our dedicated GLP-1 guide.
The Fat Loss stack.
A balanced protocol engineered for fat loss via targeted peptide synergy.
6 peptides, precisely sequenced.
Each peptide plays a specific role. Removing any one breaks the synergy.
Fat loss, appetite control, cardiovascular benefits
Weight loss, body recomposition, glycemic control
Superior body recomposition, massive fat loss, metabolic health
Visceral fat reduction, body recomposition
Customize this protocol
Open this protocol in the Cycle Planner to adjust duration, swap peptides, and generate your reference dosing chart.
Based on published trial data.
Estimated total cost for the Fat Loss stack (6 compounds) across verified vendors.
Totals are estimates — individual products must be added at vendor checkout. Affiliate links · Rankings independent.
Frequently asked questions.
What's the best peptide for fat loss?
Based on clinical trial data, Tirzepatide (dual GLP-1/GIP agonist) shows the strongest results at ~22% body weight reduction in the SURMOUNT trials. Semaglutide is the most widely prescribed at ~15% reduction. For research-only options, AOD-9604 targets fat-specific lipolysis and MOTS-c enhances metabolic function. → Read more at peptidex.app/best/fat-loss
What's the difference between semaglutide and tirzepatide?
Semaglutide is a GLP-1 receptor agonist (single target), while tirzepatide is a dual GLP-1/GIP agonist. Tirzepatide generally produces greater weight loss (~22% vs ~15%) in clinical trials due to the additive metabolic effects of GIP receptor activation. Both are FDA-approved. → Read more at peptidex.app/compare/semaglutide-vs-tirzepatide
Do peptides require a prescription?
Only FDA-approved peptides require a prescription: Semaglutide (Ozempic/Wegovy), Tirzepatide (Mounjaro/Zepbound), Tesamorelin (Egrifta), and PT-141 (Vyleesi). All other peptides indexed on PeptiDex are research-only compounds sold for laboratory use. → Read more at peptidex.app/faq
How long does it take for peptides to work?
Results vary by peptide. GLP-1 agonists (Semaglutide) show appetite effects within days and measurable weight loss by week 4-8. BPC-157 may show healing improvements within 1-2 weeks. GH secretagogues (CJC-1295/Ipamorelin) typically require 4-8 weeks for noticeable body composition changes. → Read more at peptidex.app/library
What is Retatrutide?
Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 2 trials showed ~24% body weight reduction at 48 weeks — the highest of any anti-obesity peptide in clinical development. Not yet FDA-approved; Phase 3 trials are ongoing. → Read more at peptidex.app/library/retatrutide